SIVA1 anticorps (N-Term)

N° du produit ABIN1450104

Détail du produit anti-SIVA1 anticorps

Antigène: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp SIVA1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid synthetic peptide near the amino terminus of human SIVA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SIVA1

Antigène: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Autre désignation: SIVA1 / SIVA (SIVA1 Produits)

Synonymes: anticorps CD27BP, anticorps SIVA, anticorps Siva-1, anticorps Siva-2, anticorps CD27bp, anticorps Siva, anticorps SIVA1 apoptosis inducing factor, anticorps SIVA1, apoptosis-inducing factor, anticorps SIVA1, anticorps Siva1

Sujet: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFk-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.Synonyms: Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP

ID gène: 10572

NCBI Accession: NP_068355

Pathways: Positive Regulation of Endopeptidase Activity