VASH1 anticorps (AA 261-310)

N° du produit ABIN1452171

Cet anticorps anti-VASH1 Polyclonal Lapin (ABIN1452171) détecte spécifiquement VASH1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour VASH1 anticorps (AA 261-310) (ABIN1452171)

Antigène: VASH1 (Vasohibin 1 (VASH1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VASH1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-VASH1 anticorps

Épitope: AA 261-310

Fonction: Vasohibin Antibody

Specificité: Vasohibin Polyclonal Antibody detects endogenous levels of Vasohibin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human VASH1. AA range:261-310

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur VASH1

Antigène: VASH1 (Vasohibin 1 (VASH1))

Autre désignation: VASH1

Sujet:

Synonyms: VASH1, KIAA1036, VASH, Vasohibin-1

Background: caution:Although probably secreted, it lacks a canonical signal sequence.,function:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.,induction:By VEGF.,PTM:2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.,similarity:Belongs to the vasohibin family.,tissue specificity:Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.,

Gene Name: VASH1

Protein Name: Vasohibin-1

Poids moléculaire: 40 kDa

ID gène: 22846

OMIM: 609011

UniProt: Q7L8A9