Cathepsin B anticorps (AA 168-217)

N° du produit ABIN1453029

Cet anticorps anti-Cathepsin B Polyclonal Lapin (ABIN1453029) détecte spécifiquement Cathepsin B dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Cathepsin B anticorps (AA 168-217) (ABIN1453029)

Antigène: Cathepsin B (CTSB)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-Cathepsin B anticorps

Épitope: AA 168-217

Fonction: Cathepsin B Antibody

Specificité: Cathepsin B Polyclonal Antibody detects endogenous levels of Cathepsin B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized peptide derived from human Cathepsin B. AA range:168-217

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Cathepsin B

Antigène: Cathepsin B (CTSB)

Autre désignation: Cathepsin B

Sujet:

Synonyms: CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1

Background: This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.

Gene Name: CTSB

Protein Name: Cathepsin B

Poids moléculaire: 37 kDa

ID gène: 1508

OMIM: 116810

UniProt: P07858

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades