ANKRD2 anticorps

N° du produit ABIN1504147

Cet anticorps Souris Monoclonal détecte spécifiquement ANKRD2 dans WB et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour ANKRD2 anticorps (ABIN1504147)

Antigène: ANKRD2 (Ankyrin Repeat Domain 2 (Stretch Responsive Muscle) (ANKRD2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ANKRD2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: YAS11

Détail du produit anti-ANKRD2 anticorps

Specificité: This antibody reacts with ARPP (43 kDa).

Réactivité croisée (Details): Species reactivity (tested):Human (TE-1).
Does not react with Mouse (NIH/3T3).

Purification: Protein A agarose

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Détails sur ANKRD2

Antigène: ANKRD2 (Ankyrin Repeat Domain 2 (Stretch Responsive Muscle) (ANKRD2))

Autre désignation: ANKRD2

Sujet: Ankyrin-repeat protein with a PEST motif and a proline-rich region (ARPP), also designated as Ankrd2, which isolated from a cDNA library of human esophageal carcinoma cell line (TE-1) is composed of 333 amino acids and contains four ankyrin-like repeat motifs in its middle portion, a PEST-like sequence and a lysine-rich sequence in the N-terminal region, and a proline-rich region in the C-terminal region. ARPP is homologous to CARP, cardiac ankyrin repeat protein (52 % identical), which is a nuclear protein and is involved in the regulation of the transcription of MLC-2s in cardiomyogenesis. In the immunohistochemical analysis of paraffin embedded sections, ARPP is found to express at a high level in almost all rhabdomyosarcomas. On the other hand in normal tissues, ARPP preferentially expresses in skeletal and cardiac muscle. Furthermore ARPP expresses in part of the distal tubule of the kidney and also expresses specifically in renal oncocytoma but barely detectable in conventional renal cell carcinoma. ARPP may have potential use as a marker for distinguishing renal oncocytoma from other renal cell carcinomas.Synonyms: ARPP, Ankyrin repeat domain-containing protein 2, Skeletal muscle ankyrin repeat protein

ID gène: 26287