TIMP2 anticorps (AA 100-200)

N° du produit ABIN1513608

Cet anticorps anti-TIMP2 est un anticorps Lapin Polyclonal détectant TIMP2 dans WB, IHC et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour TIMP2 anticorps (AA 100-200) (ABIN1513608)

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TIMP2 anticorps

Épitope: AA 100-200

Séquence: VSLDVGGKKE YLIAGKAEGD GKMHITLCDF IVPWDTLSTT QKKSLNHRYQ MGCECKITRC PMIPCYISSP DECLWMDWVT EKNINGHQAK FFACIKRSDG S

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TIMP2 (NP_003246.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-TIMP2 (ABIN1513608)

Wang, Zhang, Sun, Wang, Yang, Yang, Zhang, Luo, Wang, Jiang, Zeng, Cai, Bai: "Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2." dans: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 25, Issue 3, pp. 715-727, (2017) (PubMed).

Détails sur TIMP2

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Autre désignation: TIMP2

Sujet: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.,TIMP2,CSC-21K,DDC8,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,MMPs,Ubiquitin,Cardiovascular,Angiogenesis,TIMP2

Poids moléculaire: 24 kDa

ID gène: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process