TBC1D4 anticorps (AA 611-660)

N° du produit ABIN1532319

L’anticorps anti-TBC1D4 Polyclonal Lapin est utilisé pour la détection de TBC1D4 dans des échantillons de Humain et Souris. Il a été validé pour ELISA, IHC et IF.

Aperçu rapide pour TBC1D4 anticorps (AA 611-660) (ABIN1532319)

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBC1D4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-TBC1D4 anticorps

Épitope: AA 611-660

Fonction: TBC1D4 Antibody

Specificité: TBC1D4 Polyclonal Antibody detects endogenous levels of TBC1D4 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human AS160. AA range:611-660

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur TBC1D4

Antigène: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Autre désignation: AS160

Sujet:

Synonyms: TBC1D4, AS160, KIAA0603, TBC1 domain family member 4, Akt substrate of 160 kDa, AS160

Background: This gene is a member of the Tre-2/BUB2/CDC16 domain family.The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Ph

Gene Name: TBC1D4

Protein Name: TBC1 domain family member 4

Poids moléculaire: 146 kDa

ID gène: 9882

OMIM: 612465

UniProt: O60343