CSTB anticorps (AA 49-98)

N° du produit ABIN1533404

Cet anticorps anti-CSTB Polyclonal Lapin (ABIN1533404) détecte spécifiquement CSTB dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain et Rat.

Aperçu rapide pour CSTB anticorps (AA 49-98) (ABIN1533404)

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSTB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-CSTB anticorps

Épitope: AA 49-98

Fonction: Cystatin B Antibody

Specificité: Cystatin B Polyclonal Antibody detects endogenous levels of Cystatin B protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human Stefin B. AA range:49-98

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur CSTB

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Autre désignation: Stefin B

Sujet:

Synonyms: CSTB, CST6, STFB, Cystatin-B, CPI-B, Liver thiol proteinase inhibitor, Stefin-B

Background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens.This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG rep

Gene Name: CSTB

Protein Name: Cystatin-B

Poids moléculaire: 11 kDa

ID gène: 1476

OMIM: 601145

UniProt: P04080

Pathways: Response to Water Deprivation