TIMP2 anticorps (AA 21-70)

N° du produit ABIN1533420

Cet anticorps Lapin Polyclonal détecte spécifiquement TIMP2 dans WB, IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris. Il a été cité dans 2+ publications.

Aperçu rapide pour TIMP2 anticorps (AA 21-70) (ABIN1533420)

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIMP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-TIMP2 anticorps

Épitope: AA 21-70

Fonction: TIMP-2 Antibody

Specificité: TIMP-2 Polyclonal Antibody detects endogenous levels of TIMP-2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human TIMP2. AA range:21-70

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Références pour anticorps anti-TIMP2 (ABIN1533420)

Nishihara, Remacle, Angert, Shubayev, Shiryaev, Liu, Dolkas, Chernov, Strongin, Shubayev: "Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury." dans: The Journal of biological chemistry, Vol. 290, Issue 6, pp. 3693-707, (2015) (PubMed).

Hu, Cai, Hu, Patel, Bard, Jamison, Coling: "Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 43, pp. 14927-41, (2012) (PubMed).

Détails sur TIMP2

Antigène: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Autre désignation: TIMP2

Sujet:

Synonyms: TIMP2, Metalloproteinase inhibitor 2, CSC-21K, Tissue inhibitor of metalloproteinases 2, TIMP-2

Background: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008],

Gene Name: TIMP2

Protein Name: Metalloproteinase inhibitor 2

Poids moléculaire: 24 kDa

ID gène: 7077

OMIM: 188825

UniProt: P16035

Pathways: cAMP Metabolic Process