NUB1 anticorps (AA 566-615)

N° du produit ABIN1533431

Cet anticorps anti-NUB1 Polyclonal Lapin (ABIN1533431) détecte spécifiquement NUB1 dans WB, IHC, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Singe.

Aperçu rapide pour NUB1 anticorps (AA 566-615) (ABIN1533431)

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Reactivité: Humain, Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-NUB1 anticorps

Épitope: AA 566-615

Fonction: NUB1 Antibody

Specificité: NUB1 Polyclonal Antibody detects endogenous levels of NUB1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur NUB1

Antigène: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Autre désignation: NYREN18

Sujet:

Synonyms: NUB1; NYREN18; NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18

Background: This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events.The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici

Gene Name: NUB1

Protein Name: NEDD8 ultimate buster 1

Poids moléculaire: 70 kDa

ID gène: 51667

OMIM: 607981

UniProt: Q9Y5A7