ATRX anticorps (AA 111-160)

N° du produit ABIN1533739

L’anticorps anti-ATRX Polyclonal Lapin est utilisé pour la détection de ATRX dans des échantillons de Humain et Souris. Il a été validé pour ELISA et IF.

Aperçu rapide pour ATRX anticorps (AA 111-160) (ABIN1533739)

Antigène: ATRX (helicase 2, X-linked (ATRX))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATRX est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Détail du produit anti-ATRX anticorps

Épitope: AA 111-160

Fonction: ATRX Antibody

Specificité: ATRX Polyclonal Antibody detects endogenous levels of ATRX protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human ATRX. AA range:111-160

Isotype: IgG

Information d'application

Indications d'application: IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur ATRX

Antigène: ATRX (helicase 2, X-linked (ATRX))

Autre désignation: ATRX

Sujet:

Synonyms: ATRX, RAD54L, XH2, Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX

Background: ATRX, chromatin remodeler(ATRX) Homo sapiens The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2013],

Gene Name: ATRX

Protein Name: Transcriptional regulator ATRX

Poids moléculaire: 282 kDa

ID gène: 546

OMIM: 300032

UniProt: P46100