TNS3 anticorps (AA 541-590)

N° du produit ABIN1533957

Cet anticorps Lapin Polyclonal détecte spécifiquement TNS3 dans IHC, ELISA et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TNS3 anticorps (AA 541-590) (ABIN1533957)

Antigène: TNS3 (Tensin 3 (TNS3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TNS3 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-TNS3 anticorps

Épitope: AA 541-590

Fonction: Tensin3 Antibody

Specificité: Tensin3 Polyclonal Antibody detects endogenous levels of Tensin3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590

Isotype: IgG

Information d'application

Indications d'application: IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur TNS3

Antigène: TNS3 (Tensin 3 (TNS3))

Sujet:

Synonyms: TNS3, TEM6, TENS1, TPP, Tensin-3, Tensin-like SH2 domain-containing protein 1, Tumor endothelial marker 6

Background: function:May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.,induction:EGF induces down-regulation.,PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions.,tissue specificity:Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.,

Gene Name: TNS3

Protein Name: Tensin-3

Poids moléculaire: 155 kDa

ID gène: 64759

OMIM: 606825

UniProt: Q68CZ2