CADM1 anticorps (AA 393-442)

N° du produit ABIN1534300

L’anticorps anti-CADM1 Polyclonal Lapin est utilisé pour la détection de CADM1 dans des échantillons de Humain et Souris. Il a été validé pour WB, ELISA et IF.

Aperçu rapide pour CADM1 anticorps (AA 393-442) (ABIN1534300)

Antigène: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CADM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-CADM1 anticorps

Épitope: AA 393-442

Fonction: TSLC1 Antibody

Specificité: TSLC1 Polyclonal Antibody detects endogenous levels of TSLC1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human CADM1. AA range:393-442

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur CADM1

Antigène: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Autre désignation: CADM1

Sujet:

Synonyms: CADM1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1, Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, NECL-2, Spermatogenic immunoglobulin superfamily, SgIgSF, Synaptic cell adhesion molecule, SynCAM, Tumo

Background: disease:Absent or down-regulated in many advanced cases of NSCLC as well as in many other human cancers, due to gene silencing by promoter methylation.,domain:The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.,function:Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.,subunit:Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6.,

Gene Name: CADM1

Protein Name: Cell adhesion molecule 1

Poids moléculaire: 48 kDa

ID gène: 23705

OMIM: 605686

UniProt: Q9BY67

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation