Neurexin 1 anticorps (AA 502-551)

N° du produit ABIN1535088

Cet anticorps Lapin Polyclonal détecte spécifiquement Neurexin 1 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Neurexin 1 anticorps (AA 502-551) (ABIN1535088)

Antigène: Neurexin 1 (NRXN1)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurexin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Neurexin 1 anticorps

Épitope: AA 502-551

Fonction: Neurexin I Antibody

Specificité: Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Neurexin 1

Antigène: Neurexin 1 (NRXN1)

Autre désignation: NRXN1

Sujet:

Synonyms: NRXN1, KIAA0578, Neurexin-1-alpha, Neurexin I-alpha

Background: NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.

Gene Name: NRXN1

Protein Name: Neurexin-1-alpha

Poids moléculaire: 161 kDa

ID gène: 9378

OMIM: 600565

UniProt: Q9ULB1

Pathways: Synaptic Membrane, Skeletal Muscle Fiber Development