MYSM1 anticorps (AA 520-569)

N° du produit ABIN1535215

L’anticorps anti-MYSM1 Polyclonal Lapin est utilisé pour la détection de MYSM1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB, IHC et IF.

Aperçu rapide pour MYSM1 anticorps (AA 520-569) (ABIN1535215)

Antigène: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYSM1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-MYSM1 anticorps

Épitope: AA 520-569

Fonction: MYSM1 Antibody

Specificité: MYSM1 Polyclonal Antibody detects endogenous levels of MYSM1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MYSM1

Antigène: MYSM1 (Myb-Like, SWIRM and MPN Domains 1 (MYSM1))

Autre désignation: MYSM1

Sujet:

Synonyms: MYSM1, KIAA1915, Histone H2A deubiquitinase MYSM1, 2A-DUB, Myb-like, SWIRM and MPN domain-containing protein 1

Background: catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.,function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the peptidase M67A family. MYSM1 subfamily.,similarity:Contains 1 MPN (JAB/Mov34) domain.,similarity:Contains 1 SANT domain.,similarity:Contains 1 SWIRM domain.,subunit:Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.,

Gene Name: MYSM1

Protein Name: Histone H2A deubiquitinase MYSM1

Poids moléculaire: 95 kDa

ID gène: 114803

UniProt: Q5VVJ2

Pathways: Chromatin Binding