RIN1 anticorps (AA 655-704)

N° du produit ABIN1535259

Cet anticorps Lapin Polyclonal détecte spécifiquement RIN1 dans WB, ELISA et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour RIN1 anticorps (AA 655-704) (ABIN1535259)

Antigène: RIN1 (Ras and Rab Interactor 1 (RIN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RIN1 anticorps

Épitope: AA 655-704

Fonction: RIN1 Antibody

Specificité: RIN1 Polyclonal Antibody detects endogenous levels of RIN1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human RIN1. AA range:655-704

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur RIN1

Antigène: RIN1 (Ras and Rab Interactor 1 (RIN1))

Autre désignation: RIN1

Sujet:

Synonyms: RIN1, Ras and Rab interactor 1, Ras inhibitor JC99, Ras interaction/interference protein 1

Background: function:Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis.,PTM:Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylated on Ser-351 by PKD.,similarity:Belongs to the RIN (Ras interaction/interference) family.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 VPS9 domain.,subcellular location:Some amount is membrane-associated.,subunit:Interacts with the GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). This interaction prevents the association between RAF1 and Ras. Interacts with 14-3-3 proteins YWHAB, YWHAE and YWHAZ when phosphorylated on Ser-351. Interacts with the SH3 domain of ABL1 and ABL2. Interacts with RAB5A. The interaction with Ras is probably regulated and antagonized by the interaction with 14-3-3 proteins. The interaction with 14-3-3 proteins is regulated by phosphorylation on Ser-351.,tissue specificity:Expressed in all tissues examined with high levels in brain, placenta and pancreas.,

Gene Name: RIN1

Protein Name: Ras and Rab interactor 1

Poids moléculaire: 84 kDa

ID gène: 9610

OMIM: 605965

UniProt: Q13671