VN2R1P anticorps (AA 400-449)

N° du produit ABIN1535664

Cet anticorps Lapin Polyclonal détecte spécifiquement VN2R1P dans ELISA, WB et IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour VN2R1P anticorps (AA 400-449) (ABIN1535664)

Antigène: VN2R1P (Vomeronasal 2 Receptor 1 Pseudogene (VN2R1P))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VN2R1P est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-VN2R1P anticorps

Épitope: AA 400-449

Fonction: VN2R1P Antibody

Specificité: VN2R1P Polyclonal Antibody detects endogenous levels of VN2R1P protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human CASRL1. AA range:400-449

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur VN2R1P

Antigène: VN2R1P (Vomeronasal 2 Receptor 1 Pseudogene (VN2R1P))

Sujet:

Background: The CARL-1 monoclonal antibody reacts with human TWEAK, a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion. TWEAK transcript is expressed broadly in many adult and fetal tissues, however, the staining of human peripheral blood mononuclear cells with monoclonal antibodies shows a more restricted pattern. While freshly isolated PBMCs do not express detectable levels of TWEAK on their surface, IFN-gamma-stimulated blood monocytes rapidly upregulate TWEAK surface expression. TWEAK is expressed as membrane bound and secreted forms. Interaction of TWEAK with its counter-receptor promotes secretion of IL-8, activation of NF-kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. Initially, DR3 was thought to be a receptor for TWEAK, but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. While TWEAK exhibits overlapping signaling functions to TNF, it is generally less effective in inducing apoptosis, giving rise to its name, TNF-like weak inducer of apoptosis. For detection of human TWEAK by sandwich ELISA, a combination of purified CARL-2 for capture and biotinylated CARL-1 for detection is recommended.

Gene Name: CASRL1

Protein Name: Putative calcium-sensing receptor-like 1

Poids moléculaire: 83 kDa

ID gène: 344760

UniProt: Q8NGV9