SPTAN1 anticorps (Cleaved-Asp1185)

N° du produit ABIN1536099

Cet anticorps Lapin Polyclonal détecte spécifiquement SPTAN1 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour SPTAN1 anticorps (Cleaved-Asp1185) (ABIN1536099)

Antigène: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPTAN1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SPTAN1 anticorps

Épitope: AA 1136-1185, Cleaved-Asp1185

Fonction: Cleaved-Spectrin α II (D1185) Antibody

Specificité: Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Pureté: > 95 %

Immunogène: The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur SPTAN1

Antigène: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Autre désignation: SPTA2

Sujet:

Synonyms: SPTAN1, NEAS, SPTA2, Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit

Background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement.This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010],

Gene Name: SPTAN1

Protein Name: Spectrin alpha chain non-erythrocytic 1

Poids moléculaire: 137 kDa

ID gène: 6709

OMIM: 182810

UniProt: Q13813

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization