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USP8 anticorps (C-Term)

USP8 Reactivité: Humain WB Hôte: Souris Monoclonal 460CT35-1-6 unconjugated
N° du produit ABIN1536612
  • Antigène Voir toutes USP8 Anticorps
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Épitope
    • 10
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30, C-Term
    Reactivité
    • 46
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 44
    • 1
    • 1
    Souris
    Clonalité
    • 45
    • 1
    Monoclonal
    Conjugué
    • 26
    • 4
    • 4
    • 4
    • 4
    • 4
    Cet anticorp USP8 est non-conjugé
    Application
    • 42
    • 26
    • 18
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Homologie
    M
    Purification
    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
    Immunogène
    This USP8 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8.
    Clone
    460CT35-1-6
    Isotype
    IgG1
    Top Product
    Discover our top product USP8 Anticorps primaire
  • Indications d'application
    WB: 1:500~4000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    USP8 Antibody (C-term C1072)(Ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Date de péremption
    6 months
  • Antigène
    USP8 (Ubiquitin Specific Peptidase 8 (USP8))
    Autre désignation
    USP8 (USP8 Produits)
    Synonymes
    anticorps HumORF8, anticorps UBPY, anticorps AI574262, anticorps AW557536, anticorps Ubpy, anticorps mKIAA0055, anticorps ubiquitin carboxyl-terminal hydrolase 8, anticorps ubiquitin specific peptidase 8, anticorps LOC9310109, anticorps MGYG_00369, anticorps USP8, anticorps Usp8
    Sujet
    Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
    Poids moléculaire
    127523
    ID gène
    9101
    NCBI Accession
    NP_001122082, NP_001122083, NP_005145
    UniProt
    P40818
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