ACER1 anticorps (C-Term)

N° du produit ABIN1536908

L’anticorps anti-ACER1 Polyclonal Lapin est utilisé pour la détection de ACER1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour ACER1 anticorps (C-Term) (ABIN1536908)

Antigène: ACER1 (Alkaline Ceramidase 1 (ACER1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACER1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB37377

Détail du produit anti-ACER1 anticorps

Épitope: AA 236-263, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: ACER1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur ACER1

Antigène: ACER1 (Alkaline Ceramidase 1 (ACER1))

Autre désignation: ACER1

Sujet: Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081], Sun et al., 2008 [PubMed 17713573]).

Poids moléculaire: 31095

ID gène: 125981

NCBI Accession: NP_597999

UniProt: Q8TDN7