MC1 Receptor anticorps (AA 205-232)

N° du produit ABIN1537697

L’anticorps anti-MC1 Receptor Monoclonal Souris est utilisé pour la détection de MC1 Receptor dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour MC1 Receptor anticorps (AA 205-232) (ABIN1537697)

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MC1 Receptor est non-conjugé

Application: Western Blotting (WB)

Clone: 578CT6-2-3

Détail du produit anti-MC1 Receptor anticorps

Épitope: AA 205-232

Purification: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogène: This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.

Isotype: IgM

Information d'application

Indications d'application: WB: 1:100~250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: MC1R Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur MC1 Receptor

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Autre désignation: MC1R

Sujet: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq].

Poids moléculaire: 34706

ID gène: 4157

NCBI Accession: NP_002377

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour