TFEB anticorps (AA 271-300)

N° du produit ABIN1538221

Détail du produit anti-TFEB anticorps

Antigène: TFEB (Transcription Factor EB (TFEB))

Épitope: AA 271-300

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TFEB est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TFEB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human TFEB.

Clone: RB39331

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: TFEB Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur TFEB

Antigène: TFEB (Transcription Factor EB (TFEB))

Autre désignation: TFEB (TFEB Produits)

Synonymes: anticorps TFEB, anticorps tcfeb, anticorps MGC145796, anticorps alphatfeb, anticorps ALPHATFEB, anticorps BHLHE35, anticorps TCFEB, anticorps Tcfeb, anticorps bHLHe35, anticorps transcription factor EB, anticorps TFEB, anticorps tfeb, anticorps Tfeb

Sujet: Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Poids moléculaire: 52865

ID gène: 7942

NCBI Accession: NP_001161299, NP_001258872, NP_001258873, NP_001258874, NP_009093

UniProt: P19484