EFCAB4B anticorps (N-Term)

N° du produit ABIN1539404

Détail du produit anti-EFCAB4B anticorps

Antigène: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Épitope: AA 48-74, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EFCAB4B est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This EFCAB4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the N-terminal region of human EFCAB4B.

Clone: RB38227

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: EFCAB4B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Date de péremption: 6 months

Détails sur EFCAB4B

Antigène: EFCAB4B (EF-Hand Calcium Binding Domain 4B (EFCAB4B))

Autre désignation: EFCAB4B (EFCAB4B Produits)

Synonymes: anticorps CRACR2A, anticorps Gm1073, anticorps Gm462, anticorps calcium release activated channel regulator 2A, anticorps CRACR2A, anticorps Cracr2a

Sujet: Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Poids moléculaire: 45592

ID gène: 84766

NCBI Accession: NP_001138430, NP_116069

UniProt: Q9BSW2