DBN1 anticorps (N-Term) (PE)

N° du produit ABIN1558085

Il existe 1 publication pour ce produit. L’anticorps anti-DBN1 Monoclonal Souris est utilisé pour la détection de DBN1 dans des échantillons de Humain. Il a été validé pour ICFC.

Aperçu rapide pour DBN1 anticorps (N-Term) (PE) (ABIN1558085)

Antigène: DBN1 (Drebrin 1 (DBN1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBN1 est conjugé à/à la PE

Application: Intracellular Flow Cytometry (ICFC)

Clone: DBN-N-03

Détail du produit anti-DBN1 anticorps (PE)

Épitope: AA 1-326, N-Term

Fonction: Anti-Drebrin PE

Réactivité croisée (Details): Human

Attributs du produit: The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton.

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)

Isotype: IgG2b

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze,Protect from prolonged exposure to light

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-DBN1 (PE) (ABIN1558085)

Vaskova, Kovac, Volna, Angelisova, Mejstrikova, Zuna, Brdicka, Hrusak: "High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody." dans: Leukemia research, Vol. 35, Issue 8, pp. 1111-3, (2011) (PubMed).

Détails sur DBN1

Antigène: DBN1 (Drebrin 1 (DBN1))

Autre désignation: Drebrin

Sujet: Drebrin 1,Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.,DBN, D0S117E

ID gène: 1627

UniProt: Q16643

Pathways: Maintenance of Protein Location