14-3-3 eta anticorps

N° du produit ABIN1580407

Détail du produit anti-14-3-3 eta anticorps

Antigène: 14-3-3 eta (YWHAH)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp 14-3-3 eta est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: affinity purified antibody

Clone: 3G12

Isotype: IgG1

Information d'application

Indications d'application: Try at dilutions of 1:500-1:1,000 for immunofluorescence. For western blots try at 1:1,000-1:5,000. A suitable control tissue is rat spinal cord or peripheral nerve homogenate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4°C short term or -20°C long term.

Détails sur 14-3-3 eta

Antigène: 14-3-3 eta (YWHAH)

Autre désignation: 14-3-3eta (YWHAH Produits)

Synonymes: anticorps ywha1, anticorps 14-3-3e, anticorps YWHAH, anticorps YWHA1, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta L homeolog, anticorps YWHAH, anticorps ywhah, anticorps Ywhah, anticorps ywhah.L

Sujet: The 14.3.3 family of proteins were originally discovered as prominent protein spots on 2 dimensional gels. They are a family of 28-33 kDa proteins which are often major proteins of the cytoplasm. They function as binding partners for phosphoserine and phosphothreonine sites in other proteins, though they have other binding partners which are not dependent on phosphorylation. These binding interactions are important in the regulation of molecules such as the signaling kinases in the MAP kinase pathway, c-Raf and b-Raf, the proapoptotic molecules Bad and Bax, and the cell cycle regulator Cdc25. There are 7 mammalian 14.3.3 proteins and they are normally expressed as homo or in some cases heterodimers. 14.3.3 eta is widely expressed and concentrated in the nervous system. The HGNC name for 14.3.3 is YWHAH, and an alternate name is tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein 1, due to a role for this protein in activation of tyrosine and tryptophan hydroxylases. One result of this is that the HGNC name is YWHAH. The 14.3.3eta, protein accumulates in the CSF of patients suffering form Creutzfeld Jacob Disease, and can be used for the diagnosis of this disease. Furthermore, this protein binds alpha,-synuclein in the Lewy bodies of Parkinson's disease and has been linked to early-onset schizopherenia. The HGNC name for this protein is YWHAH. ﾠ

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, C21-Steroid Hormone Metabolic Process, Myometrial Relaxation and Contraction