KRIT1 anticorps
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- Antigène Voir toutes KRIT1 Anticorps
- KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KRIT1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificité
- Recombinant human CCM1
- Attributs du produit
- Chromosomal location: 7q21.2
- Isotype
- IgG
- Top Product
- Discover our top product KRIT1 Anticorps primaire
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- Indications d'application
- Western Blot: use 1-5 µg/mL
- Commentaires
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Rabbit IG Polyclonal Antibody
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- 0.5X PBS, pH 7.2
- Conseil sur la manipulation
- Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- Date de péremption
- 6 months
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- Antigène
- KRIT1 (KRIT1, Ankyrin Repeat Containing (KRIT1))
- Autre désignation
- CCM-1 (KRIT1 Produits)
- Synonymes
- anticorps CAM, anticorps CCM1, anticorps 2010007K12Rik, anticorps A630036P20Rik, anticorps AA432855, anticorps AI450393, anticorps AI643869, anticorps BB155247, anticorps BB235701, anticorps Ccm1, anticorps RGD1305929, anticorps krit1, anticorps fb36f07, anticorps san, anticorps santa, anticorps wu:fb36f07, anticorps zgc:63585, anticorps KRIT1, ankyrin repeat containing, anticorps KRIT1, anticorps Krit1, anticorps krit1
- Sujet
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Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM-1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos. However, cellular functions of CCM-1 during the early steps of the CCM pathogenesis remain unknown. It was shown that CCM-1 represents an antiangiogenic protein to keep the human endothelium quiescent. CCM-1 inhibits endothelial proliferation, apoptosis, migration, lumen formation, and sprouting angiogenesis in primary human endothelial cells. CCM-1 strongly induces DLL4-NOTCH signaling, which promotes AKT phosphorylation but reduces phosphorylation of the mitogen-activated protein kinase ERK. Consistently, blocking of NOTCH activity alleviates CCM-1 effects. ERK phosphorylation is increased in human CCM lesions. Transplantation of CCM-1-silenced human endothelial cells into SCID mice recapitulates hallmarks of the CCM pathology and serves as a unique CCM model system.
Synonyms: CCM-1, Cerebral cavernous malformations protein 1, KRIT1, KRIT1, ankyrin repeat containing, CAM - ID gène
- 3
- NCBI Accession
- NP_004903, NM_004912
- UniProt
- O00522
- Pathways
- Cell RedoxHomeostasis
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