CCBE1 anticorps (AA 159-251)

N° du produit ABIN1589917

Cet anticorps Lapin Polyclonal détecte spécifiquement CCBE1 dans WB et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour CCBE1 anticorps (AA 159-251) (ABIN1589917)

Antigène: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCBE1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-CCBE1 anticorps

Épitope: AA 159-251

Fonction: ccbe1 antibody

Specificité: Recombinant human ccbe1 (Tyr35-Pro406) derived from Sf9 insect cells

Attributs du produit: Chromosomal location: 18q21.32

Purification: Protein A purified

Immunogène: Highly pure (>98%) recombinant human ccbe1 (Cys159-Leu251) derived from E. coli.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: Use 2-5 μg/mL

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS

Conseil sur la manipulation: Centrifuge vial prior to opening. Avoid repeated freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.

Date de péremption: 24 months

Détails sur CCBE1

Antigène: CCBE1 (Collagen and Calcium Binding EGF Domains 1 (CCBE1))

Autre désignation: ccbe1

Sujet: Collagen and calcium binding EGF domains 1, KIAA1983,The lymphatic system comprises a vascular system separate from the cardiovascular system, essential for immune responses, fluid homeostasis and fat absorption. Lymphatic vessels develop in a complex process termed lymphangiogenesis that involves budding, migration and proliferation of lymphatic endothelial progenitor cells. A few genes, such as FLT4, FOXC2 and SOX18, are known to be critically involved in lymph vessel formation in humans. Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a critical chromosomal region containing ccbe1, encoding Collagen and Calcium-Binding EGF-domain-1, a secreted protein which is required for embryonic lymphangiogenesis in zebrafish. ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migration routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.

ID gène: 147372

NCBI Accession: NM_133459, NP_597716

UniProt: Q6UXH8