SMC5 anticorps (AA 872-1101)

N° du produit ABIN1682829

Cet anticorps anti-SMC5 est un anticorps Lapin Polyclonal détectant SMC5 dans WB. Adapté pour Humain.

Aperçu rapide pour SMC5 anticorps (AA 872-1101) (ABIN1682829)

Antigène: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMC5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMC5 anticorps

Épitope: AA 872-1101

Séquence: LTEERSRASC FTGLNPTIVQ EYTKREEEIE QLTEELKGKK VELDQYRENI SQVKERWLNP LKELVEKINE KFSNFFSSMQ CAGEVDLHTE NEEDYDKYGI RIRVKFRSST QLHELTPHHQ SGGERSVSTM LYLMALQELN RCPFRVVDEI NQGMDPINER RVFEMVVNTA CKENTSQYFF ITPKLLQNLP YSEKMTVLFV YNGPHMLEPN TWNLKAFQRR RRRITFTQPS

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 872-1101 of human SMC5 (NP_055925.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:1000 - 1:3000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SMC5

Antigène: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Autre désignation: SMC5

Sujet: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres cell lines and mediates sumoylation of shelterin complex (telosome components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.,SMC5,SMC5L1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,SMC5

Poids moléculaire: 128 kDa

ID gène: 23137

UniProt: Q8IY18