Factor I Light Chain (AA 281-380) anticorps (AbBy Fluor® 350)

N° du produit ABIN1693593

Cet anticorps anti- est un anticorps Lapin Polyclonal détectant dans WB, IF (cc) et IF (p). Adapté pour Humain.

Aperçu rapide pour Factor I Light Chain (AA 281-380) anticorps (AbBy Fluor® 350) (ABIN1693593)

Antigène: Factor I Light Chain

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: AbBy Fluor® 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Épitope: AA 281-380

Homologie: Human,Mouse,Rat,Cow,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Factor I Complement factor I light chain

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Factor I Light Chain

Sujet:

Synonyms: Factor I light chain, AHUS3, C3b INA, C3b inactivator, C3B/C4B inactivator, C3BINA, CFAI_HUMAN, CFI, Complement component I, Complement control protein factor I, Complement factor I, Complement factor I light chain, F1, factor I, FactorI, FI, I factor, , KAF, Konglutinogen activating factor, Light chain of factor I, OTTHUMP00000219728.

Background: The complement pathway is an important host defense system that contributes to both innate and acquired immunity. There are three pathways of complement activation: the classical pathway, lectin pathway and alternative pathway. Complement protein Factor I is a key serine protease that modulates the complement cascade by regulating the levels of C3 convertases. It circulates in plasma as a heavily N-glycosylated heterodimer made up of two disulfide linked chains, each carrying three N-linked oligosaccharide chains that may have both structural and functional roles in the interactions with the natural substrate and the cofactor during catalysis. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It requires protein cofactors for cleavage of these complement proteins, Factor H, CR1 or MCP are required for C3b cleavage, and C4bp or CR1 are required for C4b cleavage.

ID gène: 3426