GLUD2 anticorps (AA 21-120) (AbBy Fluor® 555)

N° du produit ABIN1697423

L’anticorps Lapin Polyclonal anti-GLUD2 a été validé pour WB, IF (cc) et IF (p). Il convient pour détecter GLUD2 dans des échantillons de Humain.

Aperçu rapide pour GLUD2 anticorps (AA 21-120) (AbBy Fluor® 555) (ABIN1697423)

Antigène: GLUD2 (Glutamate Dehydrogenase 2 (GLUD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLUD2 est conjugé à/à la AbBy Fluor® 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-GLUD2 anticorps (AbBy Fluor® 555)

Épitope: AA 21-120

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GLUD2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GLUD2

Antigène: GLUD2 (Glutamate Dehydrogenase 2 (GLUD2))

Autre désignation: GLUD2

Sujet:

Synonyms: GDH 2, GDH, GDH2, GLUDP1, Glutamate dehydrogenase 2, Glutamate dehydrogenase 2 mitochondrial, Glutamate dehydrogenase pseudogene 1.

Background: GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain.

ID gène: 2747

Pathways: Synaptic Membrane