TYROBP anticorps (AA 11-100) (Biotin)

N° du produit ABIN1699978

Cet anticorps Lapin Polyclonal détecte spécifiquement TYROBP dans ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour TYROBP anticorps (AA 11-100) (Biotin) (ABIN1699978)

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYROBP est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-TYROBP anticorps (Biotin)

Épitope: AA 11-100

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DAP12

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur TYROBP

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Autre désignation: DAP12

Sujet:

Synonyms: DAP 12, DAP12, DNAX activation protein 12, DNAX-activation protein 12, KAR-associated protein, KARAP, Killer activating receptor associated protein, Killer-activating receptor-associated protein, PLOSL, TYOBP_HUMAN, TYRO protein tyrosine kinase binding protein, TYRO protein tyrosine kinase-binding protein, TYROBP.

Background: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]