GATA3 anticorps (pSer308) (Biotin)

N° du produit ABIN1700185

Cet anticorps Lapin Polyclonal détecte spécifiquement GATA3 dans WB et ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour GATA3 anticorps (pSer308) (Biotin) (ABIN1700185)

Antigène: GATA3 (GATA Binding Protein 3 (GATA3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GATA3 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA

Détail du produit anti-GATA3 anticorps (Biotin)

Épitope: pSer308

Réactivité croisée: Souris

Homologie: Human,Dog,Cow,Sheep,Pig,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur GATA3

Antigène: GATA3 (GATA Binding Protein 3 (GATA3))

Autre désignation: GATA3

Sujet:

Synonyms: GATA3 phospho S308, p-GATA3 phospho S308, GATA3 phospho Ser308, p-GATA3 Ser308, GATA 3, GATA3, GATA-3, GATA binding factor 3, GATA binding protein 3, HDR, MGC2346, MGC5199, MGC5445, Trans acting T cell specic transcription factor GATA 3, GATA3_HUMAN, Trans-acting T-cell-specic transcription factor GATA-3, GATA-binding factor 3.

Background: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary, lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

ID gène: 2625

Pathways: Hormone Transport, Regulation of Hormone Metabolic Process, Tube Formation