IFI30 anticorps (AA 181-250) (Biotin)

N° du produit ABIN1700344

Cet anticorps Lapin Polyclonal détecte spécifiquement IFI30 dans ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour IFI30 anticorps (AA 181-250) (Biotin) (ABIN1700344)

Antigène: IFI30 (Interferon, gamma-Inducible Protein 30 (IFI30))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFI30 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-IFI30 anticorps (Biotin)

Épitope: AA 181-250

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human IFI30

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur IFI30

Antigène: IFI30 (Interferon, gamma-Inducible Protein 30 (IFI30))

Autre désignation: I30

Sujet:

Synonyms: Gamma interferon inducible lysosomal thiol reductase, Gamma interferon inducible protein IP 30, GILT, I 30, interferon gamma inducible protein 30, Interferon gamma inducible protein 30 preproprotein, IP30, Lysosomal thiol reductase, Lysosomal thiol reductase, gamma-interferon-inducible.

Background: Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is mediated enzymatically by thioredoxin. In the endocytic pathway, reduction of protein disulfide bonds is important for the generation of MHC class II-peptide complexes. This process is catalyzed by a gamma-interferon-inducible thiol reductase (GILT). GILT is synthesized as a precursor, and following delivery to MHC class II-containing compartments (MIICs), is processed to the mature form via cleavage of amino- and carboxy-terminal propeptides. A lysosomal thiol reductase, GILT, is optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro. GILT is expressed constitutively in antigen-presenting cells and is induced by g-interferon in other cell types, suggesting a potentially important role in antigen processing. Additionally, T cell recognition of select exogenous and endogenous epitopes is dependent on tumor cell expression of GILT. The absence of GILT in melanomas alters antigen processing and the hierarchy of immunodominant epitope presentation.

ID gène: 10437

UniProt: P13284