Destrin anticorps (AA 75-165) (Biotin)

N° du produit ABIN1701016

Cet anticorps Lapin Polyclonal détecte spécifiquement Destrin dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour Destrin anticorps (AA 75-165) (Biotin) (ABIN1701016)

Antigène: Destrin (DSTN) (Destrin (Actin Depolymerizing Factor) (DSTN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Destrin est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Destrin anticorps (Biotin)

Épitope: AA 75-165

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Monkey

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Destrin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Destrin

Antigène: Destrin (DSTN) (Destrin (Actin Depolymerizing Factor) (DSTN))

Autre désignation: Destrin

Sujet:

Synonyms: 2610043P17Rik, ACTDP, Actin depolymerizing factor, Actin-depolymerizing factor, ADF, AU042046, bA462D18.2, corn1, DEST_HUMAN, Destrin actin depolymerizing factor, Destrin, DSN, Dstn, Sid 23, sid23p.

Background: Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71 % sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

ID gène: 11034