GORASP2 anticorps (AA 151-250) (Biotin)

N° du produit ABIN1701529

Cet anticorps Lapin Polyclonal détecte spécifiquement GORASP2 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Xenopus laevis.

Aperçu rapide pour GORASP2 anticorps (AA 151-250) (Biotin) (ABIN1701529)

Antigène: GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))

Reactivité: Souris, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GORASP2 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GORASP2 anticorps (Biotin)

Épitope: AA 151-250

Réactivité croisée: Souris, Xenopus laevis

Homologie: Human,Rat,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Golgi phosphoprotein 6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur GORASP2

Antigène: GORASP2 (Golgi Reassembly Stacking Protein 2, 55kDa (GORASP2))

Autre désignation: Golgi phosphoprotein 6

Sujet:

Synonyms: Golgi phosphoprotein 6, Golgi reassembly stacking protein 2, Golgi reassembly stacking protein 2, 55 kDa, Golgi reassembly stacking protein of 55 kDa, Golgi reassembly-stacking protein 2, Golgi reassembly-stacking protein of 55 kDa, GOLPH2, GOLPH6, GORASP2, GORS2_HUMAN, GRASP55, GRS2, p59, RP23-428O15.1.

Background: The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5).

ID gène: 26003