TMC8 anticorps (AA 301-400) (Cy3)

N° du produit ABIN1702672

Cet anticorps Lapin Polyclonal détecte spécifiquement TMC8 dans WB, IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour TMC8 anticorps (AA 301-400) (Cy3) (ABIN1702672)

Antigène: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMC8 est conjugé à/à la Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-TMC8 anticorps (Cy3)

Épitope: AA 301-400

Homologie: Human,Mouse,Rat,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EVER2/TMC8

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TMC8

Antigène: TMC8 (Transmembrane Channel-Like 8 (TMC8))

Autre désignation: EVER2/TMC8

Sujet:

Synonyms: epidermodysplasia verrucormis 2, Epidermodysplasia verrucormis protein 2, EV2, EVIN2, FLJ40668, FLJ43684, MGC102701, MGC40121, TMC8, Transmembrane channel like protein 8, TMC8_HUMAN.

Background: Transmembrane channel-like protein 8 (TMC8), also known as Epidermodysplasia verruciformis protein 2 (EVER2), is a 726 amino acid member of the TMC family of proteins. Localized to the endoplasmic reticulum membrane, TMC8 is thought to form a transmembrane channel-like protein with eight predicted transmembrane domains and three leucine zipper motifs. Mutations in the genes encoding TMC8 and TMC6, another member of the TMC family, have been shown to cause epidermodysplasia verruciformis (EV), an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. Infection by HPVs lead to persistent wart-like or macular lesions. TMC8 is expressed in placenta, prostate and testis, and three named isoforms exist as a result of alternative splicing events.

ID gène: 147138