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IKAP/p150 anticorps (AA 1151-1250) (HRP)

ELP1 Reactivité: Souris, Rat WB, IHC (p), IHC (fro) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1711362
  • Antigène Voir toutes IKAP/p150 (ELP1) Anticorps
    IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
    Épitope
    • 14
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1151-1250
    Reactivité
    • 25
    • 24
    • 18
    • 1
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 39
    • 3
    • 3
    Lapin
    Clonalité
    • 42
    • 3
    Polyclonal
    Conjugué
    • 19
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IKAP/p150 est conjugé à/à la HRP
    Application
    • 23
    • 17
    • 13
    • 13
    • 9
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human IKAP
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Date de péremption
    12 months
  • Antigène
    IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
    Autre désignation
    IKAP (ELP1 Produits)
    Synonymes
    anticorps DYS, anticorps ELP1, anticorps FD, anticorps IKAP, anticorps IKI3, anticorps TOT1, anticorps IKBKAP, anticorps DKFZp469N1415, anticorps 3110040G09Rik, anticorps 6030413P05, anticorps C78473, anticorps Elp1, anticorps Ikbkap, anticorps elongator complex protein 1, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein, anticorps ielongator complex protein 1 S homeolog, anticorps inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein, anticorps ELP1, anticorps Elp1, anticorps IKBKAP, anticorps elp1.S, anticorps elp1, anticorps Ikbkap
    Sujet

    The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: DKFZp781H1425, DYS, Dysautonomia Riley Day syndrome hereditary sensory autonomic neuropathy type III, Elongator complex protein 1, ELP 1, ELP1, ELP1_HUMAN, FD, FLJ12497, IKAP, IkappaB kinase complex associated protein, IkappaB kinase complex-associated protein, ikbkap, IKI 3, IKI3, IKK complex associated protein, IKK complex-associated protein, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein, OTTHUMP00000063889, p150, TOT 1, TOT1

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