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DOCK4 anticorps (AA 1001-1100) (HRP)

DOCK4 Reactivité: Humain IHC (p), IHC (fro) Hôte: Lapin Polyclonal HRP
N° du produit ABIN1711661
  • Antigène Voir toutes DOCK4 Anticorps
    DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))
    Épitope
    • 14
    • 3
    • 3
    • 2
    • 1
    • 1
    AA 1001-1100
    Reactivité
    • 33
    • 11
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 30
    • 4
    Lapin
    Clonalité
    • 31
    • 3
    Polyclonal
    Conjugué
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DOCK4 est conjugé à/à la HRP
    Application
    • 14
    • 13
    • 9
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human DOCK4
    Isotype
    IgG
  • Indications d'application
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Date de péremption
    12 months
  • Antigène
    DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))
    Autre désignation
    DOCK4 (DOCK4 Produits)
    Synonymes
    anticorps DOCK4, anticorps 5330406C03, anticorps 6330411N01Rik, anticorps AF263288, anticorps C030023J22, anticorps mKIAA0716, anticorps dedicator of cytokinesis 4, anticorps DOCK4, anticorps NAEGRDRAFT_81257, anticorps Dock4
    Sujet

    DOCK 4 is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.

    Subcellular location: Cell membrane

    Synonyms: Dedicator of cytokinesis protein 4, Dock4, DOCK4_HUMAN, KIAA0716.

    ID gène
    9732
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