ZAK anticorps (AA 1-100) (HRP)

N° du produit ABIN1711753

Cet anticorps Lapin Polyclonal détecte spécifiquement ZAK dans ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour ZAK anticorps (AA 1-100) (HRP) (ABIN1711753)

Antigène: ZAK (Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZAK est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ZAK anticorps (HRP)

Épitope: AA 1-100

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZAK/HCCS4

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ZAK

Antigène: ZAK (Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK))

Autre désignation: ZAK/HCCS4

Sujet:

Synonyms: AZK, Cervical cancer suppressor gene 4 protein, HCCS 4, HCCS-4, HCCS4, Human cervical cancer suppressor gene 4 protein, Leucine zipper and sterile alpha mot containing kinase, Leucine zipper- and sterile alpha mot-containing kinase, Mitogen activated protein kinase kinase kinase MLT, Mitogen-activated protein kinase kinase kinase MLT, Mixed lineage kinase 7, Mixed lineage kinase related kinase, Mixed lineage kinase related kinase MRK beta, Mixed lineage kinase with a leucine zipper and a sterile alpha mot, Mixed lineage kinase-related kinase, MLK 7, MLK like mitogen activated protein triple kinase, MLK related kinase, MLK-like mitogen-activated protein triple kinase, MLK-related kinase, MLK7, Mlklak, MLT, MLTK, MLTK_HUMAN, MRK, Sterile alpha mot and leucine zipper containing kinase AZK, Sterile alpha mot- and leucine zipper-containing kinase AZK, ZAK.

Background: Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.

ID gène: 51776