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BNIP3 anticorps (pSer95)

BNIP3 Reactivité: Humain ELISA, IF (p), IHC (p), IF (cc), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1713649
  • Antigène Voir toutes BNIP3 Anticorps
    BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
    Épitope
    • 15
    • 14
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer95
    Reactivité
    • 96
    • 44
    • 29
    Humain
    Hôte
    • 83
    • 9
    • 7
    Lapin
    Clonalité
    • 83
    • 16
    Polyclonal
    Conjugué
    • 37
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BNIP3 est non-conjugé
    Application
    • 55
    • 26
    • 24
    • 20
    • 18
    • 13
    • 12
    • 8
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Humain
    Homologie
    Dog,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic phosphopeptide derived from human BNIP3 around the phosphorylation site of Ser95
    Isotype
    IgG
    Top Product
    Discover our top product BNIP3 Anticorps primaire
  • Indications d'application
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    BNIP3 (BCL2/adenovirus E1B 19kDa Interacting Protein 3 (BNIP3))
    Autre désignation
    BNIP3 (BNIP3 Produits)
    Synonymes
    anticorps NIP3, anticorps Nip3, anticorps BCL2 interacting protein 3, anticorps BCL2/adenovirus E1B interacting protein 3, anticorps BNIP3, anticorps Bnip3
    Sujet

    Synonyms: BNIP3 phospho S95, p-BNIP3 phospho S95, BCL2 Adenovirus E1B 19 kDa Interacting Protein 3, BCL2/adenovirus E1B 19 kDa protein interacting protein 3, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3, BNIP 3, BNIP3, BNIP3_HUMAN, NIP 3, NIP3.

    Background: The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins. BNIP-3 preferentially binds to Bcl-xL and induces apoptosis by suppressing the anti-apoptosis activity of Bcl-xL.

    ID gène
    664
    Pathways
    Autophagy, Brown Fat Cell Differentiation
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