LIMA1 anticorps (AA 161-260)

N° du produit ABIN1713685

Détail du produit anti-LIMA1 anticorps

Antigène: LIMA1 (LIM Domain and Actin Binding 1 (LIMA1))

Épitope: AA 161-260

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIMA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human EPLIN

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur LIMA1

Antigène: LIMA1 (LIM Domain and Actin Binding 1 (LIMA1))

Autre désignation: EPLIN (LIMA1 Produits)

Synonymes: anticorps eplin, anticorps LIMA1, anticorps EPLIN, anticorps MGC146397, anticorps SREBP3, anticorps 1110021C24Rik, anticorps 3526402A12Rik, anticorps D15Ertd366e, anticorps Eplin, anticorps LIM domain and actin binding 1, anticorps Lima1, anticorps LIMA1, anticorps lima1

Sujet:

Synonyms: 1110021C24Rik, Epithelial protein lost in neoplasm, Epithelial protein lost in neoplasm beta, EPLIN, FLJ38853, LIM domain and actin binding 1, LIM domain and actin binding protein 1, LIM domain and actin-binding protein 1, LIMA1, LIMA1_HUMAN, MGC131726, SREBP3, Sterol regulatory element binding protein 3.

Background: Epithelial protein lost in neoplasm (EPLIN) is a cytoskeleton-associated protein characterized by the presence of a single centrally located lin-11, isl-1 and mec-3 (LIM) domain. It also contains at least two Actin-binding domains, in which the C-terminal domain binds more effectively than the N-terminal domain. By binding Actin monomers and filaments, EPLIN is involved in regulation of the Actin cytoskeleton by increasing the number and size of Actin stress fibers, delaying filament nucleation, reducing formation of branched filaments and bundling of Actin filaments. It also inhibits membrane ruffling and Actin filament depolymerization. EPLIN is strongly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart, and to a lesser degree in lung, liver, brain, skeletal muscle, thymus, testis and intestine. It is expressed as two isoforms, EPLIN- and EPLIN-_. Downregulation of EPLIN- expression may contribute to the motility of invasive tumor cells.

ID gène: 51474