GRB14 anticorps (AA 221-320)

N° du produit ABIN1713832

Cet anticorps Lapin Polyclonal détecte spécifiquement GRB14 dans ELISA, IF (cc), IF (p), IHC (p), ICC et IHC (fro). Il présente une réactivité envers Humain.

Aperçu rapide pour GRB14 anticorps (AA 221-320) (ABIN1713832)

Antigène: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB14 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GRB14 anticorps

Épitope: AA 221-320

Specificité: This antibody may also detect the similar protein GRB10 due to an 83 % sequence similarity in the immunogen sequence.

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GRB 14

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur GRB14

Antigène: GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))

Autre désignation: GRB 14

Sujet:

Synonyms: Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14

Background: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

ID gène: 2888

UniProt: Q14449