NOSTRIN anticorps (AA 301-400)

N° du produit ABIN1713872

L’anticorps anti-NOSTRIN Polyclonal Lapin est utilisé pour la détection de NOSTRIN dans des échantillons de Humain. Il a été validé pour IF (cc), IF (p), IHC (p) et IHC (fro).

Aperçu rapide pour NOSTRIN anticorps (AA 301-400) (ABIN1713872)

Antigène: NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOSTRIN est non-conjugé

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-NOSTRIN anticorps

Épitope: AA 301-400

Fonction: NOSTRIN Polyclonal Antibody

Homologie: Human,Mouse,Rat,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NOSTRIN

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur NOSTRIN

Antigène: NOSTRIN (Nitric Oxide Synthase Trafficker (NOSTRIN))

Autre désignation: NOSTRIN

Sujet:

Synonyms: BM247, BM247 homolog, DaIP2, eNOS-trafficking inducer, mDaIP2, MGC20702, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, NOSTN_HUMAN, Nostrin, RP23-431D4.2

Background: NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.