RAPGEF6 anticorps (AA 601-700)

N° du produit ABIN1713889

Cet anticorps Lapin Polyclonal détecte spécifiquement RAPGEF6 dans IF (cc), IF (p), IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour RAPGEF6 anticorps (AA 601-700) (ABIN1713889)

Antigène: RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPGEF6 est non-conjugé

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-RAPGEF6 anticorps

Épitope: AA 601-700

Fonction: RAGEF2 Polyclonal Antibody

Homologie: Human,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RAGEF2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RAPGEF6

Antigène: RAPGEF6 (Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6))

Autre désignation: RAGEF2

Sujet:

Synonyms: DKFZp667N084, DKFZp686I15116, KIA001LB, PDZ domain containing guanine nucleotide exchange factor GEF 2, PDZ domain containing guanine nucleotide exchange factor 2, PDZ domain containing guanine nucleotide exchange factor I, PDZ domain-containing guanine nucleotide exchange factor 2, PDZ GEF 2, PDZ GEF2, PDZ-GEF2, PDZGEF 2, PDZGEF2, RA GEF 2, RA GEF2, RA-GEF-2, RAGEF 2, Rap guanine nucleotide exchange factor GEF 6, Rap guanine nucleotide exchange factor 2, Rap guanine nucleotide exchange factor 6, RAPGEF6, RPGF6_HUMAN.

Background: RAPGEF6 is a guanine nucleotide exchange factor (GEF) that is expressed in a variety of tissues. Localizing to the cytoplasm and translocated to the plasma membrane upon ligand binding, RAPGEF6 contains an N-terminal Ras-GEF domain, a cyclic nucleotide monophosphate-binding domain, a PDZ (PSD-95/DlgA/ZO-1) domain, a Ras-associating (RA) domain and a Ras exchanger motif. RAPGEF6 is closely related to RAPGEF2 and both proteins exhibit GEF activity specific towards Rap 1 and Rap 2. In addition, RAPGEF6 is capable of binding to M-Ras via its RA domain. Due to alternative splicing events, two additional isoforms exist for RAPGEF6, namely PDZ-GEF2A and PDZ-GEF2B.