TRRAP anticorps (AA 3401-3600)

N° du produit ABIN1714098

Détail du produit anti-TRRAP anticorps

Antigène: TRRAP (Transformation/transcription Domain-Associated Protein (TRRAP))

Épitope: AA 3401-3600

Reactivité: Humain, Rat, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRRAP est non-conjugé

Application: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Rat, Xenopus laevis

Homologie: Mouse,Dog,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TRRAP

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur TRRAP

Antigène: TRRAP (Transformation/transcription Domain-Associated Protein (TRRAP))

Autre désignation: TRRAP (TRRAP Produits)

Synonymes: anticorps PAF350/400, anticorps PAF400, anticorps STAF40, anticorps TR-AP, anticorps Tra1, anticorps AI481500, anticorps TRRAP, anticorps trrap, anticorps transformation/transcription domain associated protein, anticorps phosphotransferases/inositol or phosphatidylinositol kinase, anticorps transcription-associated protein 1, anticorps transformation/transcription domain-associated protein, anticorps TRRAP, anticorps AT4G36080, anticorps LOC5577036, anticorps Trrap, anticorps trrap, anticorps LOC100637779

Sujet:

Synonyms: 350/400 kDa PCAF associated factor, FLJ10671, PAF 350/400, PAF 400, PAF350/400, PAF400, STAF 40, STAF40, TR AP, Tra 1, Tra1, Tra1 homolog, Transactivation / transformation domain associated protein, Transactivation/transformation domain associated protein, Transformation/transcription domain associated protein, TRAP, TRRAP_HUMAN.

Background: The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1). E2F-1 is thought to regulate c-Myc expression via interactions with the retinoblastoma protein (2). TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3). TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5).

ID gène: 8295