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BOP1 anticorps (AA 201-300)

BOP1 Reactivité: Souris WB, IF (cc), IF (p), IHC (p), ELISA, IHC (fro), ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714117
  • Antigène Voir toutes BOP1 Anticorps
    BOP1 (Block of Proliferation 1 (BOP1))
    Épitope
    • 14
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 201-300
    Reactivité
    • 19
    • 18
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 32
    Lapin
    Clonalité
    • 32
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp BOP1 est non-conjugé
    Application
    • 13
    • 12
    • 12
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human BOP1
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    BOP1 (Block of Proliferation 1 (BOP1))
    Autre désignation
    BOP1 (BOP1 Produits)
    Synonymes
    anticorps AU020183, anticorps AW146150, anticorps D18861, anticorps Erb1p, anticorps Kiaa0124, anticorps mKIAA0124, anticorps bop1-B, anticorps id:ibd1283, anticorps si:ch211-251g8.2, anticorps si:ch211-251g8.4, anticorps zgc:154135, anticorps MCG5033, anticorps bop1-a, anticorps bop1-b, anticorps Block of proliferation 1, anticorps block of proliferation 1, anticorps block of proliferation 1 L homeolog, anticorps block of proliferation 1 S homeolog, anticorps GL50803_8035, anticorps Mbre_bop1, anticorps Bop1, anticorps bop1.L, anticorps BOP1, anticorps bop1, anticorps bop1.S
    Sujet

    Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.

    Subcellular location: Nucleus

    Synonyms: AU020183, AW146150, Block of proliferation 1, Block of proliferation 1 protein, Bop1, Bop1 block of proliferation 1, BOP1_HUMAN, D18861, Erb1p, Kiaa0124, MGC109114, mKIAA0124, Ribosome biogenesis protein BOP1.

    ID gène
    23246
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