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FZR1 anticorps (AA 141-240)

FZR1 Reactivité: Humain, Souris WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1714172
  • Antigène Voir toutes FZR1 Anticorps
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Épitope
    • 14
    • 10
    • 9
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 141-240
    Reactivité
    • 57
    • 30
    • 15
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 51
    • 6
    Lapin
    Clonalité
    • 51
    • 6
    Polyclonal
    Conjugué
    • 21
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FZR1 est non-conjugé
    Application
    • 33
    • 21
    • 12
    • 12
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human FZR1/CDC20C
    Isotype
    IgG
  • Indications d'application
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Date de péremption
    12 months
  • Antigène
    FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
    Autre désignation
    FZR1/CDC20C (FZR1 Produits)
    Synonymes
    anticorps CDH1-C, anticorps FYR, anticorps FZR, anticorps CDH1, anticorps fzr1, anticorps CDC20C, anticorps FZR2, anticorps HCDH, anticorps HCDH1, anticorps AW108046, anticorps Cdh1, anticorps Fyr, anticorps zgc:55450, anticorps fizzy and cell division cycle 20 related 1, anticorps fizzy/cell division cycle 20 related 1, anticorps fizzy-related protein homolog, anticorps fizzy/cell division cycle 20 related 1 (Drosophila), anticorps fizzy/cell division cycle 20 related 1a, anticorps Fzr1, anticorps CDH1-C, anticorps FZR1, anticorps LOC100027495, anticorps LOC100179951, anticorps fzr1a
    Sujet

    Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

    Subcellular location: Cytoplasm, Nucleus

    Synonyms: FZR, FZR2, CDC20C, Fizzy-related protein homolog, CDC20-like protein 1, Cdh1/Hct1 homolog, FZR1, FYR, KIAA1242

    ID gène
    51343
    UniProt
    Q9UM11
    Pathways
    DNA Replication, Synthesis of DNA
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