PTPN23 anticorps (AA 1501-1636)

N° du produit ABIN1714283

L’anticorps anti-PTPN23 Polyclonal Lapin est utilisé pour la détection de PTPN23 dans des échantillons de Humain et Rat. Il a été validé pour WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p) et ICC.

Aperçu rapide pour PTPN23 anticorps (AA 1501-1636) (ABIN1714283)

Antigène: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN23 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Détail du produit anti-PTPN23 anticorps

Épitope: AA 1501-1636

Réactivité croisée: Humain, Rat

Homologie: Mouse,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human HDPTP

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PTPN23

Antigène: PTPN23 (Protein Tyrosine Phosphatase, Non Receptor Type 23 (PTPN23))

Autre désignation: HDPTP

Sujet:

Synonyms: DKFZP564F0923, EC 3.1.3.48, HD PTP, HD-PTP, HDPTP, His domain containing protein tyrosine phosphatase, His domain protein tyrosine phosphatase, His domain-containing protein tyrosine phosphatase, KIAA1471, Protein tyrosine phosphatase non receptor type 23, protein tyrosine phosphatase non-receptor type 23, Protein tyrosine phosphatase TD 14, protein tyrosine phosphatase TD14, PTN23_HUMAN, PTP TD14, PTP-TD14, PTPN 23, PTPN23, Tyrosine protein phosphatase non receptor type 23, Tyrosine-protein phosphatase non-receptor type 23.

Background: HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.

ID gène: 25930