Glycogen Synthase 1 anticorps (pSer645)

N° du produit ABIN1714645

Cet anticorps Lapin Polyclonal détecte spécifiquement Glycogen Synthase 1 dans WB, ELISA, IHC (p), ICC, IF (cc), IF (p) et IHC (fro). Il présente une réactivité envers Rat et Chien.

Aperçu rapide pour Glycogen Synthase 1 anticorps (pSer645) (ABIN1714645)

Antigène: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Reactivité: Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glycogen Synthase 1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Glycogen Synthase 1 anticorps

Épitope: pSer645

Réactivité croisée: Chien, Rat

Homologie: Human,Mouse,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human Glycogen synthase 1 around the phosphorylation site of Ser645

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur Glycogen Synthase 1

Antigène: Glycogen Synthase 1 (GYS1) (Glycogen Synthase 1 (Muscle) (GYS1))

Autre désignation: Glycogen synthase 1

Sujet:

Synonyms: Glycogen synthase 1 phospho S645, Glycogen synthase 1 phospho Ser645, p-Glycogen synthase 1 S645, Glycogen synthase 1 muscle, Glycogen synthase 1, GSY, GYS, GYS1, EC 2.4.1.11, Glycogen synthase1, GYS 1, Starchsynthase muscle, UDP glucose glycogen glucosyltransferase, GYS1_HUMAN, Glycogen [starch] synthase, muscl.

Background: Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70 % identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation.

Pathways: Signalisation PI3K-Akt, AMPK Signaling, Cellular Glucan Metabolic Process