Complement Component C9b (C9b) (AA 251-350) anticorps

N° du produit ABIN1714714

Détail du produit

Antigène: Complement Component C9b (C9b)

Épitope: AA 251-350

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Complement component C9b

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Référence

Pauly, Agarwal, Dana, Schäfer, Biber, Wunderlich, Jabri, Straub, Zhang, Gautam, Weber, Hauck, Kim, Curcio, Stambolian, Li, Grosche: "Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina." dans: Cell reports, Vol. 29, Issue 9, pp. 2835-2848.e4, (2019) (PubMed).

Détail du antigène

Antigène: Complement Component C9b (C9b)

Autre désignation: Complement component C9b (C9b Produits)

Synonymes: anticorps C9, anticorps complement C9, anticorps proteasome (prosome, macropain) subunit, alpha type 4, anticorps C9, anticorps Psma4

Sujet:

Synonyms: CO9_HUMAN, Complement component C9, Complementcomponent C9b.

Background: C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 Molecules. These polymerized C9 Molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.

ID gène: 735