MLLT1 anticorps (AA 414-472)

N° du produit ABIN1721516

Détail du produit anti-MLLT1 anticorps

Antigène: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Épitope: AA 414-472

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MLLT1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Reacts with human ENL.

Purification: Purified (protein G)

Immunogène: Maltose-binding fusion protein containing ENL amino acids 414-472 (Accession no. NP_005925).

Clone: 3-1-1

Isotype: IgG1

Information d'application

Indications d'application: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB(1 - 5 μg/mL)

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.4.

Conseil sur la manipulation: Dilute in PBS or medium that is identical to that used in the assay system.

Stock: -20 °C

Stockage commentaire: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MLLT1

Antigène: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Autre désignation: ENL (MLLT1 Produits)

Synonymes: anticorps MGC84026, anticorps MLLT1, anticorps ENL, anticorps LTG19, anticorps YEATS1, anticorps AA407901, anticorps BAM11, anticorps MLLT1, super elongation complex subunit, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 L homeolog, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1, anticorps Mllt1, anticorps MLLT1, anticorps mllt1.L, anticorps mllt1

Sujet: The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. The ENL family includes ENL and AF9 and has structural homology to the yeast Anc1 protein. ENL is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells as well as in yeast. Deletion muta-genesis demonstrated that the minimal portion of ENL required for activation of transcription was localized to its C-terminal 90 amino acids. This region is highly conserved between ENL and AF9 and is retained in all Hrx-ENL and Hrx-AF9 fusion proteins. Thus, the leukemogenic contribution and transcriptional activation potential of ENL colocalize to its highly conserved carboxy terminus.

Protein ENL YEATS domain-containing protein 1 LTG19 YEATS1 Gene name : MLLT1

ID gène: 4298

UniProt: Q03111